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Pharmacology: Pharmacodynamics: Cinnarizine is a piperazine derivative with antihistamine, sedative, and calcium-channel blocking activity.
Pharmacokinetics: Cinnarizine is absorbed from the gastro-intestinal tract, peak plasma concentrations occurring 2 to 4 hours after oral administration. It undergoes metabolism and has half-life of 3 to 6 hours. Cinnarizine is excreted in the feces mainly as unchanged drug, and in the urine predominantly as metabolites.
